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., 1997). It was confirmed this effect was mediated throughout the CB1 receptor and happened at a dose that was not connected to clear Unwanted side effects. This review also shown a rise in thermal hyperalgesia and mechanical allodynia by administration of SR141716a alone, primary the authors to infer the existence of the endogenous tone of cannabinoid analgesia in neuropathy. Nonetheless, the proof for such tone in the course of inflammation is controversial (Beaulieu et al