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., 1997). It had been verified that this influence was mediated through the CB1 receptor and happened at a dose which was not associated with clear Unwanted side effects. This review also demonstrated a rise in thermal hyperalgesia and mechanical allodynia by administration of SR141716a alone, top the authors to infer the existence of the endogenous tone of cannabinoid analgesia in neuropathy. Nevertheless, the proof for this kind of tone through inflammation is controversial (Beaulieu et al
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